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海外学者云课堂《病毒动力学建模及数据分析》

发布时间:2021-05-05 12:28:16  浏览次数: 次  来源:


讲座题目1:Recent developments in modeling HIV infection and treatment

讲座时间:2021510日(周),上午800-11:00(北京时间)    

腾讯会议:936 5484 7630 ,密码:202105

报告人: 荣礼彬,副教授,美国佛罗里达大学                          

摘要:Highly active antiretroviral therapy can suppress viral replication but cannot eradicate the virus. Mathematical models, combined with experimental data, have provided important insights into HIV dynamics, immune responses, and drug treatment. However, there are still a lot of questions that remain unanswered, for example, are some drugs more effective than others? whether treatment intensification brings benefits? what causes multiple infection that may lead to drug resistance and immune escape? are there any other sources, besides the latent infection, that contribute to HIV persistence despite long-term therapy? In this lecture, I will present some recent modeling efforts in addressing these issues and also discuss their implications for the management of HIV infection.

讲座题目2:Modeling HCV dynamics

讲座时间:2021512日(周),上午800-11:00(北京时间)

腾讯会议:936 5484 7630 ,密码:202105

报告人: 荣礼彬,副教授,美国佛罗里达大学

摘要:Traditional therapy with interferon is not effective in treating chronic hepatitis C virus (HCV) infection. New treatment using direct-acting antiviral agents (DAAs) has significantly increased the cure rate. These new DAA drugs directly interfere with different steps of the HCV life cycle. Thus, the classical viral dynamic models that do not consider intracellular processes may not be optimal in analyzing data from patients treated with these drugs. In this lecture, I will discuss some advances in developing multi-scale mathematical models that can study HCV dynamics under therapy with new drugs. I will address model analysis, approximation, comparison with experimental data, as well as the implications for developing new treatment strategies for hepatitis C.

讲座题目3Within-host dynamics of influenza virus infection

讲座时间:2021516日(周),上午800-11:00(北京时间)

腾讯会议:936 5484 7630 ,密码:202105

报告人: 荣礼彬,副教授,美国佛罗里达大学

摘要:Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control within an individual with an uncomplicated influenza virus infection are not fully understood. In this lecture, I will address this by reviewing existing work and presenting a model including immune responses. I will discuss the relative roles of target cell availability, and innate and adaptive immune responses in controlling the virus. I will also discuss combination therapy for influenza.

报告人简介:荣礼彬副教授1996年至2003年在复旦大学获得数学学士和硕士学位,2007年在美国Purdue大学数学系获得博士学位,2007-2009在美国洛斯-阿拉马斯 (Los Alamos) 国家实验室做博士后研究员。2010-2017年在美国Oakland大学数学系和生物医学中心工作,先后担任助理教授、副教授(2014),自2017年8月至今任美国佛罗里达大学数学系副教授。研究领域包括生物数学、病毒动力系统、免疫学建模以及数学传染病学等,近年来他在病毒动力学及其在生物医学方面的应用研究方面取得重要进展,论文获得美国能源部国家实验室的2012年Leon Heller奖和2014年美国奥克兰大学Marian Wilson奖。2013年获得奥克兰大学最佳研究奖。2014年获得美国自然科学基金会资助青年科学家的最高奖励---NSF CAREER Award。相关论文发表在包括科学杂志子刊Science Translational Medicine,PNAS,BMC Medicine, PLoS Computational Biology,Proc. R. Soc. B,SIAM J. Appl. Math.等知名学术期刊上。目前担任《Bulletin of Mathematical Biology》、《Mathematical Biosciences》等多个杂志编委。


邀请人: 沈明望,副教授,西安交通大学公共卫生学院




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